Preston Marx
professor

Department(s):
Tropical Medicine

Email:
pmarxj@tulane.edu

Research Interests:
Simian models for AIDS pathogenesis; HIV vaccines; strategies for preventing HIV transmission to women

Professional Achievements:
1987 Outstanding Research Achievement Award University of California Davis.
1993-present Reviewer (selected list) - Science, Nature, PNAS, Journal of Virology, Vaccines, AIDS Research & Human Retroviruses, AIDS Journal, Nature Medicine
1994-2001 Member, Aaron Diamond AIDS Research Center & Head of AIDS Animal Models Laboratory at TRPRC-Tulane University Medical Center, Covington, LA
1998-2001 Member AIDS and Related Diseases Study Section NIAID
1998-2001 Executive advisory board, Pediatric AIDS Foundation
1998-present Core Scientist, Tulane University Health Sciences Center, Tulane National Primate Research Center, Division of Microbiology and Immunology, Covington, LA
2000-2004 AIDS Research Advisory Committee (ARAC), NIH, NIAID, Bethesda, MD
2005-present Editor-in-Chief, Journal of Medical Primatology

Educational Background:
BS, biology, University of New Orleans, New Orleans, LA
PhD, microbiology, Louisiana State University Medical Center, New Orleans, LA
Post-doctorate, virology, St. Jude’s Children’s Research Hospital, Memphis, TN

Publications:
Ling, B., R.S. Veazey, A. Luckay, C. Penedo, K. Xu, J.D. Lifson and P.A. Marx. SIVmac pathogenesis in rhesus of Chinese and Indian origin compared with primary HIV infections in humans. AIDS 2002; 16:1489-1496.

Shacklett, B.L., B. Ling, R.S. Veazey, A. Luckay, W.J. Moretto, D.T. Wilkens, J. Hu, Z.R. Israel, D.F. Nixon and P.A. Marx. Boosting of SIV-specific T-cell responses in rhesus macaques that resist repeated intravaginal challenge with Sivmac251. AIDS Research and Human Retroviruses 2002; 14:1081-1088.

Veazey, R.S., B. Ling, H. McClure, A.A. Lackner and P.A. Marx. Vaginal CD4+ T cells express high levels of CCR5 and are rapidly depleted in Simian Immunodeficiency Virus infection. Journal of Infectious Diseases 2003; 187:769-776.

Veazey, R.S., R.J. Shattock, M. Pope, J.C. Kirijan, J. Jones, Q. Hu, T. Ketas, P.A. Marx, P.J. Klasse, D.R. Burton and J.P. Moore. Prevention of virus transmission to macaque monkeys by a vaginally applied monoclonal antibody to HIV-1 gp120. Nature Medicine 2003; 9:343-346.

Apetrei, C., D.L. Robertson and P.A. Marx. The history of SIVs and AIDS: epidemiology, phylogeny and biology of isolates from naturally SIV infected non-human primates (NHP) in Africa. In Frontiers in Bioscience 2004; 9:225-254.

Ling B, Apetrei C, Pandrea I, Veazey RS, Lackner AA, Gormus B, Marx PA: Classic AIDS in a sooty mangabey after 18 year natural infection. J Virol 2004; 78: 8902-8909.

Apetrei C and Marx PA: Arguments against simian retroviral zoonoses. Lancet 2004, 364: 137-138.

Apetrei Cristian, Michael J. Metzger, David Richardson, Binhua Ling, Paul T. Telfer, Patricia Reed, David L. Robertson, Preston A. Marx Detection and Partial Characterization of Simian Immunodeficiency Virus SIVsm Starins From Bush Meat Samples from Rural Sierra Leone. Journal of Virology 2005; 79:2631-2636.

Traina-Dorge, Vicki L., R. Lorino, B. Gormus, M. Metzger, P. Telfer, D. Richardson, D.L. Robertson, P.A. Marx, C. Apetrei. Molecular epidemiology of simian T-cell lymphotropic virus type 1 in wild and captive sooty mangabeys. Journal of Virology 2005; 79:2541-2548.

Marx, Preston A. Unsolved questions over the origin of HIV and AIDS. ASM News 2005; 71:15-20.

Apetrei, C., N.W. Lerche, I. Pandrea, B. Gormus, G. Silvestri, A. Kaur, D.L. Robertson, J.M. Hardcastle, A.A. Lackner and P.A. Marx. Kuru experiments triggered the emergence of pathogenic SIVmac. AIDS 2006; 20(3):317-321.

Apetrei, C., J. Becker, M. Metzger, R. Gautam, J. Engle, A.K. Wales, M. Eyong, P. Enyong, B.T. Foley, E. Drucker, and P.A. Marx. Potential for HIV transmission through unsafe injections. AIDS 2006; 20:1074-1076.

Gautam R, Carter AC, Katz N, Butler IF, Barnes M, Hasegawa A, Ratterree M, Silvestri G, Marx PA, Hirsch VM, Pandrea I, Apetrei C. In vitro characterization of primary SIVsmm isolates belonging to different lineages. Virology 2007; 362(2):257-70.

Gautam R, Gaufin T, Butler I, Gautam A, Barnes M, Mandell D, Pattison M, Tatum C, Macfarland J, Monjure C, Marx PA, Pandrea I, Apetrei C. SIVrcm, a unique CCR2-tropic virus, selectively depletes memory CD4+ T cells in pigtailed macaques through expanded coreceptor usage in vivo. J Virol. 2009 Jun 3. [Epub ahead of print]

Contact Information:
Chair, Division of Microbiology
Tulane National Primate Research Center
18703 Three Rivers Road
Covington, LA 70433
Phone 504.862.8040, ext. 6501
Fax 504.862.8041

Level of Instruction:
graduate