Donald Krogstad
professor

Department(s):
Global and Community Health - BSPH
Tropical Medicine

Email:
krogstad@tulane.edu

Research Interests:
Molecular and genetic basis of resistance to chloroquine and quinine; techniques for the characterization of individual clones of malaria parasites; development of methods to study pathogenicity

Professional Achievements:
1983-1989 Scientific program chair, American Society of Tropical Medicine and Hygiene
1989-1992 Councilor, president-elect and president, American Society of Tropical Medicine and Hygiene
1996-1998 Burroughs-Wellcome New Initiatives in Malaria Research Award
2000-2006 Secretary for the Medical Sciences, American Association for the Advancement of Science

Government Advisory Committees:
1990-1993 VA Merit Review Board in infectious diseases
1990-1994 NIH Recombinant DNA Advisory Committee
1991-1995 NIH US-Japan Panel on Parasitic Diseases (member, 1991-92; chair of the US Panel, 1993-95)
1995-2001 Member, Tropical Medicine and Parasitology Study Section, NIH
2001-2003 Global Expertise Reserve for the National Intelligence Council, Department of State
2004-2009 Drug Development and Antimicrobial Resistance Study Section, NIH

Educational Background:
MD, Harvard Medical School, 1965-1969
AB, Bowdoin College, 1961-1965
Research Fellow, Infectious Diseases Unit, Massachusetts General Hospital, 1975-78

Publications:
Mayence A, Vanden Eynde JJ, Krogstad FM, Krogstad DJ, Cushion MT, Huang TL: Parallel solution-phase synthesis of conformationally restricted congeners of pentamidine and evaluation of their antiplasmodial activities. J Med Chem 2004; 47 (10): 2700-2705.
Ramanathan-Girish S, Catz P, Creek MR, Wu B, Thomas D, Krogstad DJ, De D, Mirsalis JC, Green CE: Pharmacokinetics of the antimalarial drug, AQ-13, in rats and cynomolgous macaques. Intl J Toxicol 2004; 23: 179-189.

Ylostälo J, Randall AC, Myers TA, Metzger M, Krogstad DJ, Cogswell FB: Transcriptome profiles of host gene expression in a monkey model of human malaria. J Infect Dis 2005; 191 (3): 400-409.

Rogers LB, Kaack MC, Rasmussen T, Henson EW, Veazey RS, Krogstad DJ, Davison BB: Hematologic and immunophenotypic reference values for normal rhesus monkey (Macaca mulatta) umbilical cord blood: gravidity may play a role in study design. J Med Primatol 2005; 34 (3): 147-153.

Davison BB, Kaack MB, Rogers LB, Rasmussen KK, Rasmussen T, Henson EW, Montenegro S, Henson MC, Mzayek F, Krogstad DJ: Alterations in the profile of blood cell types during malaria in previously unexposed primigravid monkeys. J Infect Dis 2005; 191 (11): 1940-1952.

Lakshmanan V, Bray PG, Verdier-Pinard D, Johnson DJ, Horrocks P, Muhle RA, Alakpa GE, Hughes RH, Ward SA, Krogstad DJ, Sidhu ABS, Fidock DA: A critical role for the pfcrt K76T mutation in Plasmodium falciparum verapamil-reversible resistance. EMBO J 2005; 24(13): 2294-2305.

Muehlenbein MP, Alger J, Cogswell FB, James MA, Krogstad DJ: The reproductive endocrine response to Plasmodium vivax infection in Hondurans. Am J Trop Med Hyg 2005; 73 (1): 178-187.

Colborn JM, Koita OA, Cissé O, Bagayoko MW, Guthrie E, Krogstad DJ: Identifying and quantifying genotypes in polyclonal infections due to single species. Emerg Infect Dis 2006; 12: 475-482.

Deng H, Liu H, Krogstad FM, Krogstad DJ: Sensitive fluorescence HPLC assay for AQ-13, a candidate antimalarial, that also detects chloroquine and N-dealkylated metabolites. J Chromatogr B 2006; 833: 122-128.

Mzayek F, Deng H, Mather FJ, Wasilevich EC, Liu H, Hadi C, Chansolme DH, Murphy HA, Melek BH, Tenaglia AN, Mushatt DM, Dreisbach AW, Lertora JJL, Krogstad DJ: Randomized controlled trial of AQ-13, a candidate antimalarial, and chloroquine. PLoS Clin Trials 2007; 2 (1): e6.

Liu H, Deng H, Hocart SJ, Krogstad DJ: Solid phase synthesis of a library of 4-amino-7-chloroquinoline candidate antimalarials using a resin ‘capture’ and ’release’ strategy. J Combinatorial Chem (revised and resubmitted, September 2006).

Colborn JM, Byrd BD, Koita OA, Krogstad DJ: Effects of AT/GC content and template length on estimates of copy number using real-time PCR. Nucleic Acids Res (submitted, November 2006).

Ylostälo J, Colborn JM, Koita OA, Cissé O, Bagayoko MW, Krogstad DJ: Host gene expression in human subjects with malaria. J Clin Invest (submitted, December 2006).

Koita OA, Ibrah M, Lamine M, Maiga MS, Bouaré M, Traoré S. Coulibaly A, Bagayoko D, Barry MA, Diallo A, Krogstad DJ: Solar ultraviolet B radiation (UV-B) and malaria in Mali. Environ Health Perspect (submitted, January 2007).

Cogswell FB, De D, Henson EW, Deng H, Liu H, Collins WE, Krogstad FM, Didier PJ, Krogstad DJ: Preclinical studies of aminoquinolines active against chloroquine- and multiply-resistant Plasmodium falciparum. Am J Trop Med Hyg (submitted, February 2007).

Hocart SJ, De D, Krogstad FM, Krogstad DJ: Differential quantitative structure-activity relationships for antiplasmodial aminoquinoline analogues that circumvent resistance in Plasmodium falciparum in vitro (for submission to J Med Chem, February/March 2007).

Tsai YL, Krogstad DJ: Directed transfection in Plasmodium falciparum: targeting of the Toxoplasma gondii dhfr-ts gene to chromosomes 7 and 13 (for submission to Parasitology, March 2007).

Koehler JW, Bolton M, Rollins A, Snook K, deHaro E, Henson E, Rogers L, Martin LN, Krogstad DJ, James MA, Rice J, Davison B, Veazey RS, Prabhu R, Amedee AM, Garry RF, Cogswell FB. Altered immune responses in rhesus macaques co-infected with SIV and Plasmodium cynomolgi: an animal model for coincident AIDS and relapsing malaria. PLoS One. 2009 Sep 23;4(9):e7139.

Contact Information:
Henderson Professor and Chair, Tropical Medicine
Director, Tulane Center for Infectious Diseases
Tulane Univesity School of Public Health and Tropical Medicine
1440 Canal Street, Suite 2210
New Orleans, LA 70112
Phone 504.988.3552
Fax 504.988.6686

Level of Instruction:
graduate