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 Mark Wiser    

Mark Wiser, PhD
Associate Professor
Department of Tropical Medicine
Tulane University School of Public Health and Tropical Medicine
1440 Canal Street, Suite 2210
New Orleans, LA 70112
Phone: (504) 988-2507
Fax: (504) 988-6686
wiser@tulane.edu

 


 

Personal Statement:

Dr. Wiser's primary interest is the molecular and cellular biology of protozoan parasites and their interactions with the hosts. Major research accomplishments include the description of proteins synthesized by the malaria parasite and exported to the host cell; a proposed novel secretory pathway of the malarial parasite which functions to target proteins to the host erythrocyte, as well as a characterization of protein kinases and chaperones of the malarial parasite. He also teaches a Medical Protozoology course and has written a text book (Protozoa and Human Disease) on the topic.


Research Interests:

Molecular and cellular biology of protozoan parasites and their interactions with host cells; host-parasite interactions


Educational Background:

  • BA, biology, Franklin College, Franklin, IN
  • PhD, cell biology, University of Minnesota, Minneapolis, MN
  • Post-doctorate, biochemical parasitology, Max Planck Institute for Cell Biology, Heidelberg, Germany

Professional Achievements:

  • 1999 Excellence in Teaching Award, Tulane University School of Public Health and Tropical Medicine
  • 2002 Tulane University Health Sciences Center Teaching Scholar Award
  • 2004 Asesor Cientifico, Grupo de Bioquimica y Biologia Celular, Instituto Nacional de Salud, Bogotá, Colombia
  • 2006 Profesor Visitante Ad-Honorem de la Facultad de Medicina, Universidad Nacional de Colombia, Bogotá
  • 2009 Adjunct Assistant Professor, Department of Microbiology and Immunology, Tulane University, School of Medicine

 

Selected Publications:

Wiser, M.F. (2011) Protozoa and Human Disease. Garland Science (Taylor Francis Group) ISBN 978-0-8153-6500-6, 218 pages.


Wiser, M.F. (2008) Leishmaniasis. In Diseases and Disorders (editors, A. Hildyard and J. Goddard) Marshall Cavendish, Tarrytown, New York, Volume 2, page 509.

Wiser, M.F. (2007) Export and trafficking of Plasmodium proteins into the host erythrocyte. Acta Biológica Colombiana 12: 3-18.


Wiser, M.F.
2003. A Plasmodium homologue of cochaperone p23 and its differential expression during the replicative cycle of the malaria parasite. Parasitol. Res. 90, 166-170.


Cort
és, G.T., E. Winograd and M.F. Wiser. 2003. Characterization of proteins localized to a novel subcellular compartment and alternate secretory pathway within the malaria parasite. Mol. Biochem. Parasitol.129: 127-135.


Lanners, H.N, R.A. Bafford and M.F. Wiser. 1999. Characterization of the parasitophorous vacuole membrane from Plasmodium chabaudi and implications about its role in the export of parasite proteins. Parasitol. Res. 85: 349-355.


Wiser, M.F.
, H.N. Lanners and R.A. Bafford.  1999. Export of Plasmodium proteins via a novel alternate secretory pathway. Parasitology Today 15: 194-198.


Wiser, M.F.
, D.J. Grab and H.N. Lanners. 1999. An alternate secretory pathway in Plasmodium: more questions than answers. Pages 199-214 in Transport and Trafficking in the Malaria-Infected Erythrocyte. Wiley, Chichester (Novartis Foundation Symposium No. 226). (ISBN 0-471-99893-1)


Jennings, G.J., C.S. Toebe, A. van Belkum, and M.F. Wiser.  1998. The complete sequence of Plasmodium berghei merozoite surface protein-1 and its inter- and intraspecies variability.  Mol. Biochem. Parasitol. 93:  43-55.


Giraldo, L.E., D.J. Grab and M.F. Wiser. 1998. Molecular characterization of a Plasmodium chabaudi erythrocyte membrane-associated protein with glutamate-rich tandem repeats. J. Euk. Microbiol. 45: 528-534.


Gor, D.O., A.C. Li, M.F. Wiser and P.J. Rosenthal. 1998.  Plasmodial serine repeat antigen homologues with properties of schizont cysteine proteases. Mol. Biochem. Parasitol. 95, 153-158.


Toebe, C.S., J.D. Clements, L. Cardenas, G.J. Jennings, and M.F. Wiser.  1997.  Evaluation of immunogenicity of an oral Salmonella vaccine expressing recombinant Plasmodium berghei merozoite surface protein-1.  Am. J. Trop. Med. Hyg. 56:  192-199.


Wiser,
M.F
., C.S. Toebe and G.J. Jennings.  1997.  An additional primary proteolytic processing site in merozoite surface protein-1 of Plasmodium berghei.  Mol. Biochem. Parasitol. 85:  125-129.


Wiser, M.F.
, H.N. Lanners, R.A. Bafford and J.M. Favaloro.  1997.  A novel alternate secretory pathway for exported Plasmodium proteins.  Proc. Natl. Acad. Sci. 94:  9108-9113.


Wiser, M.F.
, J.D. Lonsdale-Eccles, A. D'Alessandro and D.J. Grab.  1997.  A cryptic protease from Trypanosoma cruzi revealed by preincubation with kininogen at low temperatures.  Biochem. Biophys. Res. Commun. 240: 540-544.


Wiser, M.F.
, G.J. Jennings, P. Uparanukraw, A. van Belkum, L.J. van Doorn and N. Kumar.  1996.  Further characterization of a 58 kDa Plasmodium berghei phosphoprotein as a cochaperone.  Mol. Biochem. Parasitol. 83:  25-33.


Wiser, M.F.
, G.J. Jennings, J.M. Lockyer, A. van Belkum and L.J. van Doorn.  1995.  Chaperonin (HSP60)-like repeats in a Plasmodium berghei phosphoprotein.  Parasitol. Res. 81:  167-169.

Gitt, M.A., M.F. Wiser, H. Leffler, J. Herrmann, Y.-R. Xia, S.M. Massa, D.N.W. Cooper, A.J. Lusis and S.H. Barondes.  1995.  Sequence and mapping of a b-galactoside-binding lectin, galectin-5, found in rat erythrocytes.  J. Biol. Chem. 270:  5032-5038.


Wiser, M.F.
  1995.  Proteolysis of a 34 kDa phosphoprotein coincident with a decrease in protein kinase activity during the erythrocytic schizont stage of the malaria parasite.  J. Euk. Microbiol. 42:  659-664.

Shinondo, C.J., H.N. Lanners, R.C. Lowrie, Jr., and M.F. Wiser.  1994.  Effect of pyrimethamine resistance on sporogony in a Plasmodium berghei/Anopheles stephensi model.  Exp. Parasitol. 78:  194-202.


Wiser, M.F.
, L.V.V. Faur, H.N. Lanners, M. Kelly and R.B. Wilson.  1993.  Accessibility and distribution of intraerythrocytic antigens of Plasmodium-infected erythrocytes following mild glutaraldehyde fixation and detergent extraction.  Parasitol. Res. 79:  579-588.


Wiser, M.F.
and H.N. Lanners.  1992.  The rapid transport of the acidic phosphoproteins of Plasmodium berghei and P. chabaudi from the intraerythrocytic parasite to the host membrane using a miniaturized fractionation procedure.  Parasitol. Res. 78:  193-200.


Wiser, M.F.
  1991.  Malarial proteins that interact with the erythrocyte membrane and cytoskeleton.  Exp. Parasitol. 73:  515-523.


Wiser, M.F.
, and H.-G. Schweiger.  1985.  Cytosolic protein kinase activity associated with the maturation of the malaria parasite Plasmodium berghei.  Mol. Biochem. Parasitol. 17: 179-189.


Wiser, M.F.
, P.A. Wood, J.W. Eaton, and J.R. Sheppard.  1983.  Membrane associated phosphoproteins in Plasmodium berghei infected murine red cells.  J. Cell Biol. 97: 196-201.


 

Level of Instruction:

graduate


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Department of Tropical Medicine, 1440 Canal Street, Suite 2210, New Orleans, LA 70112, 504-988-3558 tropmed@tulane.edu