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 Nirbhay Kumar    

Nirbhay Kumar, PhD
Professor and Chair
Department of Tropical Medicine
Tulane University School of Public Health and Tropical Medicine
1440 Canal Street, Suite 2210
New Orleans, LA 70112
Phone 504.988.2577
Fax 504.988.7313
nkumar@tulane.edu

Check out the Kumar Lab webpage




Personal Statement

Dr. Kumar's studies focus on the biochemistry, molecular biology and immunology of antigens expressed in the sexual stages of malaria parasite and host-parasite interaction. Some of the major projects currently include: (i) molecular mechanisms of sexual differentiation in Plasmodium, (ii) development of a malaria transmission blocking vaccine, (iii) characterization of malarial 'recombinosome', (iv) immune- and molecular epidemiology of malaria studies in Zimbabwe and Zambia, (v) malaria and helminth co-infections in mouse models and in humans, (vi) sporozoite – salivary gland interactions, (vii) determinants of malaria transmission success, (viii) K+ channels and malaria transmission, (ix) malaria specific memory B cell responses, (x) development of transgenic murine malaria parasites as tools to investigate transmission blocking vaccines.


Research Interests:

Immunobiology of malaria transmission; Malaria Transmission blocking vaccine; Natural Immunity to Malaria; Recombination mechanisms in Plasmodium; Helminth – Plasmodium co-infections; Animal models for human malaria vaccines; Host-Parasite adaptation including Parasite-vector interactions

Educational Background:

  • B.Sc., Agra University, India, 1970
  • M.Sc., Banaras Hindu University, Varanasi, India, 1972
  • Ph.D., All India Institute of Medical Sciences (AIIMS), New Delhi, India, 1977

Professional Achievements, Honors, Awards, & Recognitions:

  • 1993: Member Steering Committee on Immunology of Malaria, TDR, World HealthOrganization
  • 1994-1997: Expert Member, Scientific Advisory Committee, Department of Biotechnology, Ministry of Science & Technology, Government of India
  • 1999: ASM-UNESCO-Visiting Resource Program
  • 2002: Life Science 2002 Invention of the Year award, "Malaria Detection and Diagnosis." APL
  • 2002: JHU-APL, R.W.Hart Prize in Research honoring Excellence in Independent Research and Development
  • 2002: JHU-APL Publication Award for an Outstanding Research Paper in an Externally Refereed Publication
  • 2003: R. Barclay McGhee Memorial Lecture, American Society of Parasitology
  • 2005: Ranbaxy Science Foundation Medical Sciences (Basic Science) Award
  • 2007: Elected AAAS Fellow (American Association for the Advancement of Sciences)
  • 2008: Gairdner Symposium lecture
  • 2011: Chair, Travel Awards Committee of the American Society of Tropical Medicine and Hygiene
  • 2012: Elected Fellow, American Academy of Microbiology
  • 2013: Member, Education Committee, Association of Medical Schools of Microbiology and Immunology Chairs

Selected Recent Publications (Out of >150 published):

Kumar R, Angov E, Kumar N. (2014). Potent malaria transmission blocking antibody responses elicited by Plasmodium falciparum Pfs25 expressed in E.coli after successful protein refolding. Infect Immun. [Epub ahead of print]

Mlambo G, Coppens I, Kumar N. (2013). Correction: Aberrant Sporogonic Development of Dmc1 (a Meiotic Recombinase) Deficient Plasmodium berghei Parasites.
PLoS One, 1, 8(10).

Reiter K, Mukhopadhyay D, Zhang H, Boucher LE, Kumar N, Bosch J, Matunis MJ. (2013). Identification of biochemically distinct properties of the small ubiquitin-related modifier (SUMO) conjugation pathway in Plasmodium falciparum. J Biol Chem.,  288(39), 27724-36.

Sreenivasamurthy SK, Dey G, Ramu M, Kumar M, Gupta MK, Mohanty AK, Harsha HC, Sharma P, Kumar N, Pandey A, Kumar A, Prasad TS. (2013). A compendium of molecules involved in vector-pathogen interactions pertaining to malaria. Malar J, 12, 216.

Li Y, Kumar N, Gopalakrishnan A, Ginocchio C, Manji R, Bythrow M, Lemieux B, Kong H. (2013). Detection and species identification of malaria parasites by isothermal tHDA amplification directly from human blood without sample preparation. J Mol Diagn, 15(5), 634-41.

Kumar R, Nyakundi R, Kariuki T, Ozwara H, Nyamongo O, Mlambo G, Ellefsen B, Hannaman D, Kumar N. (2013). Functional evaluation of malaria Pfs25 DNA vaccine by in vivo electroporation in olive baboons. Vaccine, 31(31), 3140-7.

Gopalakrishnan AM, Kumar N. (2013). Opposing roles for two molecular forms of replication protein A in Rad51-Rad54-mediated DNA recombination in Plasmodium falciparum. MBio., 4(3), e00252-13.

Gopalakrishnan AM, Kundu AK, Mandal TK, Kumar N. (2013). Novel nanosomes for gene delivery to Plasmodium falciparum-infected red blood cells. Sci Rep., 3, 1534.

Kumar S, Zheng H, Sangweme DT, Mahajan B, Kozakai Y, Pham PT, Morin MJ, Locke E, Kumar N.
(2013). A chemiluminescent-western blot assay for quantitative detection of Plasmodium falciparum circumsporozoite protein. J. Immunol. Methods, 10, 1016.


Mlambo G, Coppens, I, Kumar N.
(2012). Aberrant sporogonic development of Dmc1 (a meiotic recombinase) deficient Plasmodium berghei parasites. PLoS One, 7(12), e52480.


Chaerkaddy, R,  Kelkar, DS, Muthusamy, B, Kandasamy, K,  Dwivedi, SB, Sahasrabudde, SA, Kim, MS, Renuse, S, Pinto, SM, Sharma, R, Pawar, H, Sekhar, NR, Mohanty, AK, Getnet, D,  Yang, Y, Dash, AP, MacCallum, RM, Delanghe, B, Mlambo, G, Kumar, A,  Okulate, M, Kumar N, and Pandey, A.
(2011).A proteogenomic analysis of Anopheles gambiae using high-resolution Fourier transform mass spectrometry. Genome Research, 21, 1872-81.


Midzi, N, Zinyowera-Mutapuri, S, Sangweme, DT, Paul, NH, Makware, G, Mapingure, MP, Brouwer, KC, Mudzori, J, Hlerema, G, Chadukura, V, Mutapi, F, Kumar, N, Mduluza, T.
(2011). Efficacy of integrated school based de-worming and prompt malaria treatment on helminths-Plasmodium falciparum co-infections: A 33 months follow up. BMC International Health and Human Rights, 11,9.


Midzi, N, Zinyowera-Mutapuri, S, Mapingure, MP, Paul, NH, Sangweme, DT, Hlerema, G, Mutsaka, MJ, Tongogara, F, Makware, G, Chadukura, V, Brouwer, KC, Mutapi, F, Kumar, N, Mduluza, T.
(2011). Knowledge attitudes and practices of grade three primary schoolchildren in relation to schistosomiasis, soil transmitted helmintiasis and malaria in Zimbabwe. BMC Infectious Diseases, 11, 169.


Noland GS, Chowdhury DR, Urban JF Jr, Zavala F, Kumar N. (2010). Helminth infection impairs the immunogenicity of a Plasmodium falciparum DNA vaccine, but not irradiated sporozoites, in mice. Vaccine, 28(17), 2917-23. 

Noland, G, Chowdhury, D, Urban, J., Fried, B and Kumar N. (2010). Reduced immunogenicity of a malaria subunit vaccine in helminth infected mice. Vaccine, 28, 2917-2923.


Mlambo, G, Kumar, N, Yoshida, S.
(2010). Functional immunogenicity of baculovirus expressing Pfs25, a human malaria transmission-blocking vaccine candidate antigen. Vaccine, 28, 7025-9.


Sangweme, DS, Midzi, N, Mutapuri, S, Mduluza, T, Diener-West, M & Kumar, N.
(2010).  Impact of schistosome infections on Plasmodium falciparum malariometeic índices and immune correlates in school age children in Burma Valley, Zimbabwe. PLos NTD, 4, e882.


Bhowmick IP, Kumar N, Sharma S, Coppens I, Jarori GK. (2009). Plasmodium falciparum enolase: stage-specific expression and sub-cellular localization. Malar J., 8, 179.


Sangweme D, Shiff C, Kumar N. (2009) Plasmodium yoelii: adverse outcome of non-lethal P. yoelii malaria during co-infection with Schistosoma mansoni in BALB/c mouse model. Exp Parasitol., 122(3), 254-9. 


Sangweme, D., Shiff, C and Kumar, N.
(2009). Adverse outcome of nonlethal Plasmodium yoelii malaria during co-infection with Schistosoma mansoni in a mouse model. Experimental Parasitology, 122, 254-259,


Ghosh AK,  Devenport M, Jethwaney D, Kalume DE, Pandey A, Anderson VE, Sultan AA, Kumar N, and Jacobs-Lorena M.
(2009). Malaria parasite invasion of the mosquito salivary gland requires interaction between the Plasmodium trap and the Anopheles Saglin proteins. Plos Pathogen, 5(1), e100265.

Nyunt, MM, Hendrix, CW, Bakhshi, R, Kumar, N, Shapiro, TA. (2009). Phase I/II evaluation of the prophylactic antimalarial activity of pafuramidine in health volunteers challenged with Plasmodium falciparum sporozoites. Am. J. Trop. Med. Hyg. 80, 528.

Chen, X, Xie, S, Kumar, N, Shapiro, T. and Liu, J. (2009). Fumagillin and Fumarranol interact with P. falciparum methionine aminopeptidase 2 and inhibit parasite growth in vitro and in vivo. Chemistry & Biology, 16, 193-202.


Chowdhury DR, Angov E, Kariuki T, Kumar N. (2009). A potent malaria transmission blocking vaccine based on codon harmonized full length Pfs48/45 expressed in Escherichia coli. PLoS One, 4(7), e6352.


Ellekvist E, Maciel J, Mlambo G, Ricke CH, Colding H, Klaerke DA, and Kumar N. (2008). Critical role of a K+ channel in Plasmodium berghei transmission revealed by targeted gene disruption. Proc. Natl. Acad. Sci., 105, 6398-6402.


Mahajan, B, Selvapandiyan, A, Gerald, NJ, Majam, V, Zheng, H, Tiwari, J, Fujioka, H, Moch, JK, Kumar, Nirbhay, Nakhashi, HL, Kumar, S.
(2008). Centrins, cell cycle regulation proteins in human malaria parasite Plasmodium falciparum. J. Biol. Chem., 283, 31871-83.


LeBlanc, R, Vasquez, Y, Hannaman, D and Kumar, N.
(2008). Markedly enhanced immunogenicity of a Pfs25 DNA based malaria transmission blocking vaccine by in vivo electroporation. Vaccine, 26, 185-192.


Mlambo, G, Maciel, J and Kumar, N.
(2008). Development of a mouse model to evaluate malaria transmission blocking vaccines using a transgenic Plasmodium berghei expressing target antigen Pfs25. Infection & Immunity, 76, 2018-2024.

Mlambo, G. and Kumar, N.
(2008). Transgenic rodent Plasmodium berghei: tools for assessment of functional immunogenicity and optimization of human malaria vaccines. Eukaryotic CELL, 7, 1875-1979.


Mlambo, G, Vasquez, Y, LeBlanc, E, Sullivan, D, Kumar, N.
(2008). An RT-PCR based detection of Plasmodium falciparum gametocytes using blood collected on filter papers. Am. J. Trop. Med. Hyg., 78, 114-116.


Noland GS, Urban JF, Fried B,and Kumar, N.
(2008). Counter-regulatory anti-parasite cytokine responses during concurrent Plasmodium yoelii and intestinal helminth infections in mice. Experimental Parasitology, 19, 272-278.


Okulate, M., Kalume, D.E., Kristiansen, T., Bhattacharyy, M.K., Pandey, A. , and Kumar, N.
(2007). Identification and molecular characterization of a novel protein SAGLIN recognized by monoclonal antibodies affecting infectivity of Plasmodium sporozoite infectivity of salivary glands in An. gambiae. Insect Molecular Biology, 16, 711-722.


Mlambo, G. and Kumar, N.
(2007).A modified Plasmodium falciparum growth inhibition assay (GIA) to assess activity of plasma from malaria endemic areas. Exp. Parasitology, 115, 211-214.


Kumar, N
. (2007). A vaccine to prevent transmission of human malaria: a long way to travel on a dusty and often bumpy road. Current Science, 92, 1535-1543.


Promeneur, D., Liu, Y., Maciel, J., Agre, P. and Kumar, N.
(2007). Evidence for a role of the Plasmodium berghei aquaglyceroporin (pbAQP) in the intrerythrocytic development of the malaria parasite. Proc. Natl. Acad. Sci. USA, 104, 2211-2216.


Liu
Y, Promeneur D, Rojek A, Kumar N, Frøkiær J, Nielsen S, King LS, Agre P, and Carbrey JM. (2007). Aquaporin 9 is the major pathway for glycerol uptake by mouse erythrocytes, with implications for malarial virulence. Proc. Natl. Acad. Sci., 104, 12560-64.


Level of Instruction:

Graduate


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Department of Tropical Medicine, 1440 Canal Street, Suite 2210, New Orleans, LA 70112, 504-988-3558 tropmed@tulane.edu