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 Donald Krogstad    

Donald Krogstad, MD
Professor
Department of Tropical Medicine
Tulane University School of Public Health and Tropical Medicine
1440 Canal Street, Suite 2210
New Orleans, LA 70112
Phone: (504) 988-3552
Fax: (504) 988-6686
krogstad@tulane.edu

 



Research Interests:

  • Molecular and genetic basis of resistance to chloroquine and quinine
  • Techniques for the characterization of individual clones of malaria parasites
  • Development of methods to study pathogenicity


Educational Background:

  • MD, Harvard Medical School, 1965-1969
  • AB, Bowdoin College, 1961-1965
  • Research Fellow, Infectious Diseases Unit, Massachusetts General Hospital, 1975-78

Professional Achievements:

  • 1983-1989 Scientific program chair, American Society of Tropical Medicine and Hygiene
  • 1989-1992 Councilor, president-elect and president, American Society of Tropical Medicine and Hygiene
  • 1996-1998 Burroughs-Wellcome New Initiatives in Malaria Research Award
  • 2000-2006 Secretary for the Medical Sciences, American Association for the Advancement of Science Government Advisory Committees:
  • 1990-1993 VA Merit Review Board in infectious diseases
  • 1990-1994 NIH Recombinant DNA Advisory Committee
  • 1991-1995 NIH US-Japan Panel on Parasitic Diseases (member, 1991-92; chair of the US Panel, 1993-95)
  • 1995-2001 Member, Tropical Medicine and Parasitology Study Section, NIH
  • 2001-2003 Global Expertise Reserve for the National Intelligence Council, Department of State
  • 2004-2009 Drug Development and Antimicrobial Resistance Study Section, NIH


Selected Publications:

 

Billo MA, Diakité M, Dolo A, Diallo M, Poudiougou B, Diawara SI, Johnson ES, Rice JC, Krogstad DJ, Doumbo OK. (2013). Inter-observer agreement according to malaria parasite density. Malar J, 12, 335.

Koita OA, Sangaré L, Sango HA, Dao S, Keita N, Maiga M, Mounkoro M, Fané Z, Maiga AS, Traoré K, Diallo A, Krogstad DJ. (2012). Effect of seasonality and ecological factors on the prevalence of the four malaria parasite species in northern Mali. J Trop Med. 2012, 367160.

Volkman SK, Ndiaye D, Diakite M, Koita OA, Nwakanma D, Daniels RF, Park DJ, Neafsey DE, Muskavitch MA, Krogstad DJ, Sabeti PC, Hartl DL, Wirth DF. (2012). Application of genomics to field investigations of malaria by the international centers of excellence for malaria research. Acta Trop., 121(3), 324-32.

Doumbia SO, Ndiaye D, Koita OA, Diakité M, Nwakanma D, Coulibaly M, Traoré SF, Keating J, Milner DA Jr, Ndiaye JL, Sene PD, Ahouidi A, Dieye TN, Gaye O, Okebe J, Ceesay SJ, Ngwa A, Oriero EC, Konaté L, Sy N, Jawara M, Faye O, Kéita M, Cissé M, Sogoba N, Poudiougou B, Diawara S, Sangaré L, Coulibaly T, Seck I, Abubakar I, Gomis J, Mather FJ, Sissako A, Diarra A, Kandeh B, Whalen C, Moyer B, Nnedu O, Thiero O, Bei AK, Daniels R, Miura K, Long CA, Fairhurst RM, Duraisingh M, Muskavitch MA, D'Alessandro U, Conway DJ, Volkman SK, Valim C, Wirth DF, Krogstad DJ. (2012). Improving malaria control in West Africa: interruption of transmission as a paradigm shift. Acta Trop.,121(3), 175-83.

Ceesay SJ, Bojang KA, Nwakanma D, Conway DJ, Koita OA, Doumbia SO, Ndiaye D, Coulibaly TF, Diakité M, Traoré SF, Coulibaly M, Ndiaye JL, Sarr O, Gaye O, Konaté L, Sy N, Faye B, Faye O, Sogoba N, Jawara M, Dao A, Poudiougou B, Diawara S, Okebe J, Sangaré L, Abubakar I, Sissako A, Diarra A, Kéita M, Kandeh B, Long CA, Fairhurst RM, Duraisingh M, Perry R, Muskavitch MA, Valim C, Volkman SK, Wirth DF, Krogstad DJ. (2012). Sahel, savana, riverine and urban malaria in West Africa: Similar control policies with different outcomes. Acta Trop., 121(3), 166-74.

Londono-Renteria B, Eisele TP, Keating J, Bennett A, Krogstad DJ. (2012). Genetic diversity in the merozoite surface protein 1 and 2 genes of Plasmodium falciparum from the Artibonite Valley of Haiti. Acta Trop., 121(1), 6-12.

Billo MA, Johnson ES, Doumbia SO, Poudiougou B, Sagara I, Diawara SI, Diakité M, Diallo M, Doumbo OK, Tounkara A, Rice J, James MA, Krogstad DJ. (2012). Sickle cell trait protects against Plasmodium falciparum infection. Am J Epidemiol. 176 Suppl 7, S175-85.

Koita OA, Doumbo OK, Ouattara A, Tall LK, Konare A, Diakite M, Diallo M, Sagara I, Masinde GL, Doumbo SN, Dolo A, Tounkara A, Traore I, Krogstad DJ. (2012). False-Negative Rapid Diagnostic Tests for Malaria and Deletion of the Histidine-Rich Repeat Region of the hrp2 Gene (dagger). Am J Trop Med Hyg., 86(2), 194-8.

Hocart SJ, Liu H, Deng H, De D, Krogstad FM, Krogstad DJ. (2011). 4-aminoquinolines active against chloroquine-resistant Plasmodium falciparum: basis of antiparasite activity and quantitative structure-activity relationship analyses. Antimicrob Agents Chemother., 55(5), 2233-44.

Janka JJ, Koita OA, Traoré B, Traoré JM, Mzayek F, Sachdev V, Wang X, Sanogo K, Sangaré L, Mendelsohn L, Masur H, Kato GJ, Gladwin MT, Krogstad DJ. (2010). Increased Pulmonary Pressures and Myocardial Wall Stress in Children with Severe Malaria. J Infect Dis., 202(5): 791-800.

Krogstad DJ, Diop S, Diallo A, Mzayek F, Keating J, Koita OA, Touré YT. (2010). Informed consent in international research: the rationale for different approaches. Am J Trop Med Hyg., 83(4), 743-7.

Keating J, Krogstad DJ, Eisele TP. (2010). Malaria elimination on Hispaniola. Lancet Infect Dis., 10(5), 291-3.

Londono BL, Eisele TP, Keating J, Bennett A, Chattopadhyay C, Heyliger G, Mack B, Rawson I, Vely JF, Désinor O, Krogstad DJ. (2009). Chloroquine-resistant haplotype Plasmodium falciparum parasites, Haiti. Emerg Infect Dis., 15(5), 735-40.


Koehler JW, Bolton M, Rollins A, Snook K, deHaro E, Henson E, Rogers L, Martin LN, Krogstad DJ, James MA, Rice J, Davison B, Veazey RS, Prabhu R, Amedee AM, Garry RF, Cogswell FB. (2009). Altered immune responses in rhesus macaques co-infected with SIV and Plasmodium cynomolgi: an animal model for coincident AIDS and relapsing malaria. PLoS One, 4(9), e7139.

Koita OA, Ibrah M, Lamine M, Maiga MS, Bouaré M, Traoré S. Coulibaly A, Bagayoko D, Barry MA, Diallo A, Krogstad DJ: Solar ultraviolet B radiation (UV-B) and malaria in Mali. Environ Health Perspect (submitted, January 2007).

Cogswell FB, De D, Henson EW, Deng H, Liu H, Collins WE, Krogstad FM, Didier PJ, Krogstad DJ: Preclinical studies of aminoquinolines active against chloroquine- and multiply-resistant Plasmodium falciparum. Am J Trop Med Hyg (submitted, February 2007).

Hocart SJ, De D, Krogstad FM, Krogstad DJ: Differential quantitative structure-activity relationships for antiplasmodial aminoquinoline analogues that circumvent resistance in Plasmodium falciparum in vitro (for submission to J Med Chem, February/March 2007).

Tsai YL, Krogstad DJ: Directed transfection in Plasmodium falciparum: targeting of the Toxoplasma gondii dhfr-ts gene to chromosomes 7 and 13 (for submission to Parasitology, March 2007).

Mzayek F, Deng H, Mather FJ, Wasilevich EC, Liu H, Hadi C, Chansolme DH, Murphy HA, Melek BH, Tenaglia AN, Mushatt DM, Dreisbach AW, Lertora JJL, Krogstad DJ. (2007). Randomized controlled trial of AQ-13, a candidate antimalarial, and chloroquine. PLoS Clin Trials, 2 (1), e6.


Colborn JM, Koita OA, Cissé O, Bagayoko MW, Guthrie E, Krogstad DJ. (2006). Identifying and quantifying genotypes in polyclonal infections due to single species. Emerg Infect Dis, 12, 475-482.

Deng H, Liu H, Krogstad FM, Krogstad DJ (2006). Sensitive fluorescence HPLC assay for AQ-13, a candidate antimalarial, that also detects chloroquine and N-dealkylated metabolites. J Chromatogr B, 833, 122-128.

Liu H, Deng H, Hocart SJ, Krogstad DJ: Solid phase synthesis of a library of 4-amino-7-chloroquinoline candidate antimalarials using a resin ‘capture’ and ’release’ strategy. J Combinatorial Chem (revised and resubmitted, September 2006).

Colborn JM, Byrd BD, Koita OA, Krogstad DJ: Effects of AT/GC content and template length on estimates of copy number using real-time PCR. Nucleic Acids Res (submitted, November 2006).

Ylostälo J, Colborn JM, Koita OA, Cissé O, Bagayoko MW, Krogstad DJ: Host gene expression in human subjects with malaria. J Clin Invest (submitted, December 2006).

Ylostälo J, Randall AC, Myers TA, Metzger M, Krogstad DJ, Cogswell FB. (2005).Transcriptome profiles of host gene expression in a monkey model of human malaria. J Infect Dis, 191(3), 400-409.

Rogers LB, Kaack MC, Rasmussen T, Henson EW, Veazey RS, Krogstad DJ, Davison BB. (2005). Hematologic and immunophenotypic reference values for normal rhesus monkey (Macaca mulatta) umbilical cord blood: gravidity may play a role in study design. J Med Primatol, 34(3), 147-153.

Davison BB, Kaack MB, Rogers LB, Rasmussen KK, Rasmussen T, Henson EW, Montenegro S, Henson MC, Mzayek F, Krogstad DJ. (2005). Alterations in the profile of blood cell types during malaria in previously unexposed primigravid monkeys. J Infect Dis, 191(11), 1940-1952.

Lakshmanan V, Bray PG, Verdier-Pinard D, Johnson DJ, Horrocks P, Muhle RA, Alakpa GE, Hughes RH, Ward SA, Krogstad DJ, Sidhu ABS, Fidock DA. (2005). A critical role for the pfcrt K76T mutation in Plasmodium falciparum verapamil-reversible resistance. EMBO J, 24(13): 2294-2305.

Muehlenbein MP, Alger J, Cogswell FB, James MA, Krogstad DJ. (2005). The reproductive endocrine response to Plasmodium vivax infection in Hondurans. Am J Trop Med Hyg, 73(1), 178-187.

Mayence A, Vanden Eynde JJ, Krogstad FM, Krogstad DJ, Cushion MT, Huang TL. (2004). Parallel solution-phase synthesis of conformationally restricted congeners of pentamidine and evaluation of their antiplasmodial activities. J Med Chem, 47(10), 2700-2705. 

Ramanathan-Girish S, Catz P, Creek MR, Wu B, Thomas D, Krogstad DJ, De D, Mirsalis JC, Green CE. (2004). Pharmacokinetics of the antimalarial drug, AQ-13, in rats and cynomolgous macaques. Intl J Toxicol, 23, 179-189.


Level of Instruction:

Graduate


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Department of Tropical Medicine, 1440 Canal Street, Suite 2210, New Orleans, LA 70112, 504-988-3558 tropmed@tulane.edu