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Jeffrey Wickliffe

Jeffrey Wickliffe, PhD
Assistant Professor
Department of Global Environmental Health Sciences
Tulane University School of Public Health and Tropical Medicine
1440 Canal Street, Suite 2100
New Orleans, LA 70112
Phone: (504) 988-5374
Fax: (504) 988-1726
jwicklif@tulane.edu



Research Interests:

environmental and molecular toxicology mechanisms of genetic damage and mutagenesis; gene-environment interactions in environmental disease


Professional Achievements:

  • Environmental Mutagen Society Award of Merit, 2004
  • Texas Genetics Society Best Platform Presentation Award, 2002-2004
  • NIH/NIEHS Toxicology Training Grant, University of Texas, 2003
  • Mehlman-Legator Best Proposal Award, 2002

Educational Background:

  • NIEHS Toxicology Postdoctoral Fellowship, University of Texas Medical Branch, Galveston, TX
  • PhD (Emphasis Biology and Molecular Toxicology), Texas Tech University, Lubbock, TX
  • MS (Emphasis Environmental Toxicology), Texas A&M University, College Station, TX
  • BS (Emphasis Wildlife Ecology), Texas A&M University, College Station, TX

Selected Publications:

Cronin MA, JK Wickliffe, Y Dunina, RJ Baker. 2002. K-ras oncogene DNA sequences in pink salmon in streams impacted by the Exxon Valdez oil spill: no evidence of oil-induced heritable mutations. Ecotoxicology 11(4):233-241. PMID: 12211696

Wickliffe JK, MM Ammenheuser, JJ Salazar, SZ Abdel-Rahman, DA Hastings-Smith, EM Postlethwait, RS Lloyd, JB Ward Jr. 2003. A model of sensitivity: 1,3-butadiene increases mutant frequencies and genomic damage in mice lacking a functional microsomal epoxide hydrolase gene. Environmental and Molecular Mutagenesis 42(2):106-110. PMID: 12929123

Swartz CD, KC Donnelly, A Islamzadey, GT Rowe, WJ Rogers, GM Palatnikov, R Kasimov, TJ McDonald, JK Wickliffe, JW Bickham. 2003. Chemical contaminants and their effects in fish and wildlife from the industrial zone of Sumgayit, Republic of Azerbaijan. Ecotoxicology 12:509-521. PMID: 14680332

Abdel-Rahman SZ, MM Ammenheuser, CJ Omiecinski, JK Wickliffe, JI Rosenblatt, JB Ward Jr. 2005. Variability in human sensitivity to 1,3-butadiene: influence of polymorphisms in the 5'-flanking region fo the microsomal epoxide hydrolase gene (EPHX1). Toxicological Sciences 85(1):624-631. PMID: 15716486

Wickliffe JK, LA Galbert, MM Ammenheuser, SM Herring, J Xie, OE Masters, RS Lloyd, JB Ward. 2006. 3,4-epoxy-1-butene, a reactive metabolite of 1,3-butadiene, induces somatic mutations in Xpc-null mice. Environmental and Molecular Mutagenesis 47(1):67-70. PMID: 16094661

Wickliffe JK, YV Dunina-Barkovskaya, SP Gaschak, BE Rodgers, RK Chesser, M Bondarkov, RJ Baker. 2006. Variation in mitochondrial DNA control region haplotypes in populations of the bank vole, Clethrionomys glareolus, living in the Chornobyl environment. Environmental Toxicology and Chemistry 25(2):503-508. PMID: 16519312

Wickliffe JK, SM Herring, LA Galbert, LM Hallberg, MM Ammenheuser, OE Masters, J Xie, EC Friedberg, RS Lloyd, JB Ward, Jr. 2007. Detoxification of olefinic epoxides and nucleotide excision repair of epoxide-mediated DNA damage: insights from animal models examining human sensitivity to 1,3-butadiene. Chemico-Biological Interactions 166(1-3):226-231. PMID: 16730686

Hill CE, JK Wickliffe, AT Guerin, CJ Kinslow, KJ Wolfe, MM Ammenheuser, SZ Abdel-Rahman. 2007. The L84F polymorphism in the O6-Methylguanine-DNA-Methylransferase (MGMT) gene increases the HPRT mutant frequency in lymphocytes of tobacco smokers. Pharmacogenetics and Genomics 17(9):743-753. PMID: 17700363

Goggin M, R Loeber, S Park, V Walker, J Wickliffe, N Tretyakova. 2007. HPLC-ESI+-MS/MS analysis of N7-Guanine-N7-Guanine DNA cross-links in tissues of mice exposed to 1,3-butadiene. Chemical Research in Toxicology 20(5):839-847. PMID: 17455958

Kinslow CJ, RA El-Zein, CE Hill, JK Wickliffe, SZ Abdel-Rahman. 2008. Single nucleotide polymorphisms 5' upstream of the coding region of the NEIL2 gene influence gene transcription levels and alter levels of genetic damage. Genes, Chromosomes and Cancer 47(11):923-932. PMID: 18651651

Wickliffe JK, MM Ammenheuser, PJ Adler, SZ Abdel-Rahman, JB Ward Jr. 2009. Evaluation of frequencies of HPRT mutant lymphocytes in butadiene polymer workers in a southeast Texas facility. Environmental and Molecular Mutagenesis 50(2):82-87. PMID: 19107895

Kinslow CJ, RA El-Zein, CM Rondelli, CE Hill, JK Wickliffe, SZ Abdel-Rahman. 2009. Regulatory regions responsive to oxidative stress in the promoter of the human DNA glycosylase gene NEIL2. Mutagenesis 25(2):171-177. PMID: 19945985

Rondelli CM, RA El-Zein, JK Wickliffe, CJ Etzel, SZ Abdel-Rahman. 2010. A comprehensive haplotype analysis of the XPC genomic sequence reveals a cluster of genetic variants associated with sensitivity to tobacco-smoke mutagens. Toxicological Sciences 115:41-50. PMID: 20106949

Kietthubthew S, JK Wickliffe, H Sriplung, I Takafumi, T Chonmaitree, W Au. 2010. Association of polymorphisms in proinflammatory cytokine genes with the development of oral cancer in Southern Thailand. International Journal of Hygiene and Environmental Health 213(2):146-152. PMID: 20133197

Wickliffe JK, SZ Abdel-Rahman, C Lee, C Kormos-Hallberg, G Sood, CM Rondelli, JJ Grady, RJ Desnick, KE Anderson. 2010. CYP1A2*1F and GSTM1 alleles are associated with susceptibility to porphyria cutanea tarda. Molecular Medicine October 15, 2010 Epub. PMID: 20957336

Wang, S., Hunter, L. A., Arslan, Z., Wilkerson, MG and Wickliffe, JK. 2011. Chronic exposure to nanosized, anatase titanium dioxide is not cyto- or genotoxic to Chinese hamster ovary cells. Environmental and Molecular Mutagenesis. Epub. doi: 10.1002/em.20660


Personal Statement:

Our research and educational programs are focused on understanding, assessing, and ultimately preventing adverse human health effects associated with exposure to environmental hazards. This includes effects resulting from exposure to direct or metabolically-activated genotoxins and mutagens such as ionizing radiation, hazardous air pollutants, elemental metals, and engineered nanomaterials. We develop and use markers designed to define mechanisms of toxicity that such agents cause directly to nucleic acids or indirectly through non-genotoxic mechanisms and their influence on disease outcomes.


Level of Instruction:

graduate


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GEHS, 1440 Canal Street, Suite 2100, New Orleans, LA 70112, 504-988-5374 gehsinfo@tulane.edu