Nick Makridakis
assistant professor
Department(s):
Epidemiology
Email:
nmakrida@tulane.edu
Research Interests:
Molecular Epidemiology of cancer and other
multifactorial diseases
Professional Achievements:
ACS Clinical Research Post-Doctoral Fellowship, 1998-00
Bodosakis Fellowship Foundation Graduate School Fellowship, 1990-93
California Foundation for Biochemical Research Graduate Research Fellowship, 1990-91
Educational Background:
Postdoctoral Fellowship, University of Southern California
PhD, University of Southern California, Los Angeles, CA
BS, University of Athens, Athens, Greece
Publications:
Phipps T, Reichardt JKV and Makridakis NM. Frequency of small-scale somatic alterations in the sporadic prostate cancer genome (manuscript in preparation).
Pearce CL, Makridakis NM, Reichardt JKV, Ross RK, Pike MC, Kolonel LN, and Henderson BE. Association between the steroid 5-alpha reductase type II gene A49T missense variant and prostate cancer risk: the multiethnic cohort. Brit J Cancer (submitted).
Makridakis NM, Ferraz L, and Reichardt JKV. Genomic analysis of cancer tissue reveals that most somatic mutations occur in a novel nine nucleotide purine rich motif. Hum Mutat (submitted).
Makridakis NM, Buchanan G, Tilley W, and Reichardt JKV. Androgen metabolic genes in prostate cancer predisposition and progression. Front Biosci 2005. 10:2892-2903.
Makridakis NM and Reichardt JKV. Pharmacogenetic analysis of human steroid 5-alpha reductase type II: comparison of finasteride and dutasteride. J Mol Endocrinol 2005. 34:617-623.
Makridakis NM, Akalu A, and Reichardt JKV. Identification and characterization of somatic steroid 5-alpha reductase (SRD5A2) mutations in human prostate cancer tissue. Oncogene 2004. 23:7399-7405.
Makridakis NM and Reichardt JKV. Molecular epidemiology of androgen metabolic loci in prostate cancer predisposition and progression. J of Urol 2004. 171:S25-S29.
Pearce CL, Makridakis NM, Ross RK, Pike MC, Kolonel LN, Henderson BE, and Reichardt JKV. The SRD5A2 V89L substitution is not significantly associated with risk of prostate cancer in a multi-ethnic population. Cancer Epidemiol Biomarkers Prev 2002. 11:417-418.
Makridakis NM and Reichardt JKV. MAPA: multiplex automated primer extension analysis: simultaneous genotyping of up to four polymorphisms. BioTechniques 2001. 31:1374-1380.
Makridakis NM and Reichardt JKV. Molecular epidemiology of hormone-metabolic loci in prostate cancer. Epidemiologic Reviews 2001. 23:24-29.
Makridakis NM, di Salle E, and Reichardt JKV. Biochemical and pharmacogenetic dissection of human steroid 5-alpha reductase type II. Pharacogenet 2000. 10:407-413.
Personal Statement:
I am currently interested in identifying genetic DNA elements in the genes that may affect cancer risk or progression, and characterize their contributions individually, in conjuction and in combination with specific environmental factors (e.g. smoking, diet). Analyzing the biochemical effect of EPHX missense variants identified in colorectal cancer patients. Also, measuring the rate of genomic variation and the degree of genomic heterogeneity in cancer tissue, compared to normal adjacent tissue.
Contact Information:
Department of Epidemiology
1440 Canal Street, Suite 2000
New Orleans, LA 70112
Phone: 504.988.6809
Fax: 504.988.1568
nmakrida@tulane.edu
Level of Instruction:
graduate
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